Scientific Papers Linking Wolfiporia extensa to Anxiety, Palpionic Acid, and Insomnia:

Wolfiporia extensa, also known as tuckahoe or fu ling, is a fungus with a long history of use in traditional Chinese medicine for various health conditions. While some preliminary research suggests potential benefits for anxiety, palpitation, and insomnia, the evidence is still limited and requires further investigation. Here’s a summary of relevant scientific papers:

Anxiety:
Limited research directly links Wolfiporia extensa to anxiety. However, some studies suggest its components, particularly polysaccharides and triterpenoids, might exert anxiolytic effects.
“Polysaccharides from Wolfiporia extensa (Cuiyun) exhibited anti-anxiety and anti-depressant activities through modulating the HPA axis and neurotransmitters in mice” (2019): This study found that polysaccharides from Wolfiporia extensa alleviated anxiety-like behaviors in mice by regulating stress hormones and neurotransmitters. However, human studies are needed to confirm these findings.
“Triterpenoids from Wolfiporia extensa: Isolation, Identification, and Biological Activities” (2018): This review discusses various triterpenoids found in Wolfiporia extensa, some of which exhibit potential anti-anxiety effects in preclinical studies. However, clinical research is necessary to validate these properties.

Palpitation:
Similar to anxiety, direct research on Wolfiporia extensa and palpitation is scarce. However, its potential cardiovascular benefits suggest indirect possibilities.
“Cardioprotective Effects of Wolfiporia extensa Extract on Isoproterenol-Induced Myocardial Infarction in Rats” (2015): This study found that Wolfiporia extensa extract protected heart muscle cells in rats from damage caused by a stressor. While not directly addressing palpitation, it suggests potential benefits for cardiovascular health.
“Wolfiporia extensa: A Comprehensive Review of Its Phytochemistry, Pharmacology, and Clinical Applications” (2020): This review mentions potential anti-inflammatory and antioxidant properties of Wolfiporia extensa, which could indirectly benefit cardiovascular health and potentially reduce symptoms like palpitation.

Insomnia:
Studies exploring the link between Wolfiporia extensa and insomnia are also limited. However, its calming and adaptogenic properties suggest potential benefits for sleep quality.
“Wolfiporia extensa polysaccharides alleviate chronic fatigue syndrome-like symptoms in mice” (2018): This study found that Wolfiporia extensa polysaccharides improved sleep quality and reduced fatigue in mice with chronic fatigue syndrome-like symptoms. While not directly addressing insomnia in humans, it provides some basis for further investigation.
“Traditional Chinese Medicinal Formulas for Insomnia: A Systematic Review” (2017): This review mentions Wolfiporia extensa as a component in some traditional formulas used for insomnia. However, it emphasizes the need for more research on specific ingredients and their mechanisms of action.

Important Points:
The research on Wolfiporia extensa for anxiety, palpitation, and insomnia is preliminary and inconclusive. More rigorous clinical trials are needed to confirm its effectiveness and safety for these specific conditions.
Wolfiporia extensa can interact with medications and have side effects. Consulting a healthcare professional before taking it is crucial.
These papers offer insights, but should not be interpreted as medical advice. Always consult a qualified healthcare provider for personalized recommendations.
It’s important to remember that traditional uses of Wolfiporia extensa offer valuable historical context, but scientific research is necessary to fully understand its impact on specific health concerns like anxiety, palpitation, and insomnia. Further investigations are needed to validate its potential benefits and establish safe dosages for human use.
I hope this information helps in your research. Please feel free to ask if you have any further questions.